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KMID : 0498419830970000004
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Tropical Medicine News
1983 Volume.97 No. 0 p.4 ~ p.6
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HLA-DR Antigens in Koreans
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Kim, Se Jong
Choi, In Hong/Kim, Joo Deuk
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Abstract
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The HLA-DR antigens are most probably controlled by multiple alleles at a single locus in the HLA region, which is identical or at least closely linked to the HLA-D locus (Pickbourne et al., 1978; Lamm et al., 1978; Th. Schreuder, 1982). However, the number of loci and the size of the polymorphism in the HLA-DR region of the major histocompatibility complex (MHC) of humans probably have not been fully ascertained. The joint reports of the Eighth International Histocompatibility Workshop (1980) on the serologic and genetic characterization of the antigens or the HLA-DR locus provided a summary. So far, ten HLA-DR specificities have been defined of which HLA-DR1, DR2, DR3, DR4, DR5, and DR7, are well defined while HLA-DRw6, DRw8, DRw9, and DRw10 are less well characterized and only have provisional
status. Definition of one of these antigens, HLA-DRw6, remains unclear. The difficulties in the assignment of HLA-DRw6 is due to the absence of monospecific antisera.
Several investigators have independently reported evidence of the presence of supertypic specificities in the HLA-DR series (Doquesnoy et al., 1979; van Leeuwen et al., 1980; Park et al., 1980). One of the supertypic specifi
cities is MT which has six inclusion groups, MT1 through MT6 (Park et al., 1980).
Apart from the Workshop data there is only little information about the gene and antigen frequencies of HLA-DR in more homogenous ethnic groups. It has been considered that Koreans are composed of a relatively homogen
ous ethnic group. Therefore, we made an attempt to perform the HLA-DR typing with 150 unrelated Koreans. Furthermore, HLA-B: DR haplotype frequencies in Korean population are included to assess the gametic associations between alleles of the HLA-DR locus and alleles of other loci in the HLA region in Koreans.
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KEYWORD
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